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Arrowhead Published New Findings from 2 P-II (SHASTA-2 & MUIR) studies for Plozasiran at AHA 2023

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Arrowhead Published New Findings from 2 P-II (SHASTA-2 & MUIR) studies for Plozasiran at AHA 2023

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  • In SHASTA-2 study (n=226) of plozasiran in patients with SHTG (with TG > 500 mg/dL), two doses of 10 mg, 25 mg, or 50 mg Q12W reduced TGs and 90% patients achieved TG levels <500 mg/dL.
  • At 24 wks, plozasiran decreased serum APOC3 to -79%, TGs to -74%, and remnant cholesterol to -63%, while increasing HDL-cholesterol to +68% and showed favorable safety profile
  • In MUIR study (n=353) of plozasiran in subjects with mixed dyslipidemia (fasting TGs: 150-499 mg/dL & either LDL-cholesterol >70 mg/dL or non-HDL-cholesterol>100 mg/dL), similar doses at Q12W or Q24W, silenced APOC3 and robust reductions in atherogenic lipoproteins observed. At 24 wks, plozasiran reduced TGs to -64%, remnant cholesterol to -54%, ApoB to -19%, and Non-HDL-cholesterol to -27%, while increasing HDL-cholesterol to +51%

Ref: Arrowhead  | Image: Arrowhead

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Shivani Chandra

Shivani was a content writer at PharmaShots. She has a keen interest in recent innovations in the life sciences industry. She was covering news related to Product approvals, clinical trial results, and updates. We can be contacted at connect@pharmashots.com.

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